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Dr. Angela Cullik

Genetische Hintergründe für die Verbreitung der Extended-Spektrum Beta-Laktamase Gene blaCTX-M

• Buch (Gebunden) • Dissertation • Deutsch • Softcover (Paperback) • 21,0 x 14,8 cm (DIN A5) • XII / 174 Seiten • Neu (eingschweißt in Folie)
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  • 9783941274624
  • 978-3-941274-62-4
Unter den Gram-negativen Erregern ist Escherichia coli(E. coli) die Hauptursache nosokomialer... mehr

Unter den Gram-negativen Erregern ist Escherichia coli(E. coli) die Hauptursache nosokomialer Infektionen. Infolge von Antibiotika-Therapien kommt es zur Ausbildung von Resistenzen, bei E. coli vorwiegend gegen beta-Laktam-Antibiotika wie Penicilline und Cephalosporine (ESBL-Bildner). Diese Arbeit beschreibt die molekulargenetischen Ursachen, die zur Verbreitung der Gene für Cephalosporin-Resistenz, blaCTX-M, beitragen. Anhand einer Kollektion von E. coli Isolaten aus nosokomialen Infektionen konnte beispielhaft gezeigt werden, dass neben klonaler Ausbreitung Cephalosporin-resistenter E. coli Stämme auch spezifische mobile genetische Elemente (MGE), darunter IS26 Transposons, eine entscheidende Rolle für die Verbreitung der Resistenzgene spielen. Desweiteren wird auf die Bedeutung von Plasmiden und ihrer molekularen Strukturen bei der stabilen Weitergabe von Resistenzgenen bei E. coli eingegangen.

Titel: Genetische Hintergründe für die Verbreitung der Extended-Spektrum Beta-Laktamase Gene blaCTX-M in Escherichia coli
Autor: Dr. Angela Cullik
Erschienen: 1. Aufl. 31.12.2010
Fachbereich: Biologie
Produkttyp: Buch (Gebunden)
Produktart: Dissertation
Sprache: Deutsch
Einband: Softcover (Paperback)
Maße: 21,0 x 14,8 cm (DIN A5)
Umfang: XII / 174 Seiten
Zustand: Neu (eingschweißt in Folie)
Keywords: Antibiotika, Cefotaxim, Cefpodoxim, Cephalosporine, CTX-M, E. coli O25, ESBL, Escherichia coli, Extended-Spektrum beta-Laktamasen, H4 ST131, IncN, Insertionselemente, IS26, ISEcp1, MGE, MHK, minimale Hemmkonzentration, mobile genetische Elemente, nosokomiale Infektionen, Penicilline, Plasmide, Plasmidsequenzierung, Resistenz, Sulbactam, Transposons
Details "Genetische Hintergründe für die Verbreitung der Extended-Spektrum Beta-Laktamase Gene blaCTX-M"
Titel: Genetische Hintergründe für die Verbreitung der Extended-Spektrum Beta-Laktamase Gene blaCTX-M in Escherichia coli
Autor: Dr. Angela Cullik
Erschienen: 1. Aufl. 31.12.2010
Fachbereich: Biologie
Produkttyp: Buch (Gebunden)
Produktart: Dissertation
Sprache: Deutsch
Einband: Softcover (Paperback)
Maße: 21,0 x 14,8 cm (DIN A5)
Umfang: XII / 174 Seiten
Zustand: Neu (eingschweißt in Folie)
Keywords: Antibiotika, Cefotaxim, Cefpodoxim, Cephalosporine, CTX-M, E. coli O25, ESBL, Escherichia coli, Extended-Spektrum beta-Laktamasen, H4 ST131, IncN, Insertionselemente, IS26, ISEcp1, MGE, MHK, minimale Hemmkonzentration, mobile genetische Elemente, nosokomiale Infektionen, Penicilline, Plasmide, Plasmidsequenzierung, Resistenz, Sulbactam, Transposons
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