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Anton Volkov

Analysis of Prokaryotic Fatty Acid Double Bond Hydratases

Members of Myosin Cross-Reactive Antigen Family
• Georg-August Universität Göttingen • Buch (Gebunden) • Dissertation • Englisch • Softcover (Paperback) • 21,0 x 14,8 cm (DIN A5) • 102 Seiten • Neu (eingschweißt in Folie)
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  • 9783941274426
  • 978-3-941274-42-6
The present dissertation is focused on the phylogenetic, biochemical, structural and... mehr

The present dissertation is focused on the phylogenetic, biochemical, structural and physiological analysis of the hydratases from Streptococcus pyogenes M49 and Lactobacillus acidophilus NCFM. These hydratases belong to myosin cross-reactive antigen (MCRA) protein family for which knowledge on the biochemical and physiological function is scarce. This study provides the first line of evidences on biological significance of this protein family as ubiquitous bacterial enzymes which metabolize highly toxic unsaturated fatty acids to their less toxic and more soluble hydroxy derivatives. Determined in this work de novo crystal structure of Lactobacillus acidophilus NCFM hydratase allows to classify the hydratases to the family of flavin containing amine oxidoreductases and establishes a framework for further biochemical and structural analysis of the rest MCRAs from the pathogenic and commensal bacterial species.

Titel: Analysis of Prokaryotic Fatty Acid Double Bond Hydratases
Untertitel: Members of Myosin Cross-Reactive Antigen Family
Autor: Anton Volkov
Hochschule: Georg-August Universität Göttingen
Erschienen: 1. Aufl. 27.05.2010
Fachbereich: Biochemie, Molekularbiologie & Gentechnologie
Produkttyp: Buch (Gebunden)
Produktart: Dissertation
Sprache: Englisch
Einband: Softcover (Paperback)
Maße: 21,0 x 14,8 cm (DIN A5)
Umfang: 102 Seiten
Zustand: Neu (eingschweißt in Folie)
Keywords: Double bond, FAD, Fatty acids, Gene knockout, Hydratase, Hydroxy fatty acid, Lactobacillus, Linoleic acid, Lipids, Minimal inhibitory concentration, Myosin cross reactive antigen, Oleic acid, Prokaryotes, Streptococcus, Structure, Toxicity
Details "Analysis of Prokaryotic Fatty Acid Double Bond Hydratases"
Titel: Analysis of Prokaryotic Fatty Acid Double Bond Hydratases
Untertitel: Members of Myosin Cross-Reactive Antigen Family
Autor: Anton Volkov
Hochschule: Georg-August Universität Göttingen
Erschienen: 1. Aufl. 27.05.2010
Fachbereich: Biochemie, Molekularbiologie & Gentechnologie
Produkttyp: Buch (Gebunden)
Produktart: Dissertation
Sprache: Englisch
Einband: Softcover (Paperback)
Maße: 21,0 x 14,8 cm (DIN A5)
Umfang: 102 Seiten
Zustand: Neu (eingschweißt in Folie)
Keywords: Double bond, FAD, Fatty acids, Gene knockout, Hydratase, Hydroxy fatty acid, Lactobacillus, Linoleic acid, Lipids, Minimal inhibitory concentration, Myosin cross reactive antigen, Oleic acid, Prokaryotes, Streptococcus, Structure, Toxicity
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